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norskBlar i forfatter "Seppola, Marit"
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Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-04)The environmental temperature has profound effects on biological systems of marine aquatic organisms and plays a critical role in species distribution and abundance. Particularly during the warmer seasons, variations in habitat temperature may introduce episodes of stressful temperatures which the organisms must adapt to and compensate for to maintain physiological homeostasis. The marine environment ... -
Disentangling the immune response and host-pathogen interactions in Francisella noatunensis infected Atlantic cod
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-13)The genetic repertoire underlying teleost immunity has been shown to be highly variable. A rare example is Atlantic cod and its relatives Gadiformes that lacks a hallmark of vertebrate immunity: Major Histocompatibility Complex class II. No immunological studies so far have fully unraveled the functionality of this particular immune system. Through global transcriptomic profiling, we investigate the ... -
Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)Genome sequencing of the teleost Atlantic cod demonstrated loss of the Major Histocompatibility Complex (MHC) class II, an extreme gene expansion of MHC class I and gene expansions and losses in the innate pattern recognition receptor (PRR) family of Toll-like receptors (TLR). In a comparative genomic setting, using an improved version of the genome, we characterize PRRs in Atlantic cod with emphasis ... -
Experimental challenge of atlantic cod (Gadus morhua) with a brucella pinnipedialis strain from hooded seal (Cystophora cristata)
(Peer reviewed; Journal article; Tidsskriftsartikkel, 2016-07-14)Pathology has not been observed in true seals infected with Brucella pinnipedialis. A lack of intracellular survival and multiplication of B. pinnipedialis in hooded seal (Cystophora cristata) macrophages in vitro indicates a lack of chronic infection in hooded seals. Both epidemiology and bacteriological patterns in the hooded seal point to a transient infection of environmental origin, possibly ... -
Multiple specialised goose-type lysozymes potentially compensate for an exceptional lack of chickentype lysozymes in Atlantic cod
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-21)Previous analyses of the Atlantic cod genome showed unique combinations of lacking and expanded number of genes for the immune system. The present study examined lysozyme activity, lysozyme gene distribution and expression in cod. Enzymatic assays employing specific bacterial lysozyme inhibitors provided evidence for presence of g-Type, but unexpectedly not for c-Type lysozyme activity. Database ... -
Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-22)This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introduction of more targeted breast cancer treatments, a prolonged survival has resulted during the last decade. Consequently, an increased number of patients ... -
Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-07)Oral squamous cell carcinomas are associated with a poor prognosis, which may be partly due to functional impairment of the immune response. Lymphocyte recruitment to the tumor site is facilitated by high-endothelial venules, whereas expression of programmed-death ligand 1 (PD-L1) can impair T-cell function. Thus, we hypothesize that these factors are important in shaping the immune response in oral ... -
Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carsinoma
(Master thesis; Mastergradsoppgave, 2017-10-31)Oral squamous cell carcinomas (OSCC) are associated with a poor prognosis, which may be partly due to functional impairment of the immune response. Lymphocyte recruitment to the tumor site is facilitated by high-endothelial venules (HEV), whereas expression of programmed-death ligand 1 (PD-L1) can impair T cell function. Thus, we hypothesize that these factors are important in shaping the immune ... -
Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-14)The Pathology Atlas is an open-access database that reports the prognostic value of protein-coding transcripts in 17 cancers, including head and neck cancer. However, cancers of the various head and neck anatomical sites are specific biological entities. Thus, the aim of the present study was to validate promising prognostic markers for head and neck cancer reported in the Pathology Atlas in oral ... -
Whole transcriptome analysis of the Atlantic cod vaccine response reveals subtle changes in adaptive immunity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-28)Atlantic cod has lost the Major Histocompatibility complex class II pathway – central to pathogen presentation, humoral response and immunity. Here, we investigate the immunological response of Atlantic cod subsequent to dip vaccination with <i>Vibrio anguillarum</i> bacterin using transcriptome sequencing. The experiment was conducted on siblings from an Atlantic cod family found to be highly ...
